Structure of PDB 1yaa Chain A

Receptor sequence
>1yaaA (length=412) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
SATLFNNIELLPPDALFGIKQRYGQDQRATKVDLGIGAYRDDNGKPWVLP
SVKAAEKLIHNDSSYNHEYLGITGLPSLTSNAAKIIFGTQSDALQEDRVI
SVQSLSGTGALHISAKFFSKFFPDKLVYLSKPTWANHMAIFENQGLKTAT
YPYWANETKSLDLNGFLNAIQKAPEGSIFVLHSCAHNPTGLDPTSEQWVQ
IVDAIASKNHIALFDTAYQGFATGDLDKDAYAVRLGVEKLSTVSPVFVCQ
SFAKNAGMYGERVGCFHLALTKQAQNKTIKPAVTSQLAKIIRSEVSNPPA
YGAKIVAKLLETPELTEQWHKDMVTMSSRITKMRHALRDHLVKLGTPGNW
DHIVNQCGMFSFTGLTPQMVKRLEETHAVYLVASGRASIAGLNQGNVEYV
AKAIDEVVRFYA
3D structure
PDB1yaa Crystal structure of Saccharomyces cerevisiae cytosolic aspartate aminotransferase.
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) W140 D222 A224 K258
Catalytic site (residue number reindexed from 1) W134 D215 A217 K254
Enzyme Commision number 2.6.1.1: aspartate transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A S107 G108 T109 W140 N194 D222 A224 Y225 S255 K258 R266 S106 G107 T108 W134 N187 D215 A217 Y218 S251 K254 R262
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0043023 ribosomal large subunit binding
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0006520 amino acid metabolic process
GO:0006531 aspartate metabolic process
GO:0006532 aspartate biosynthetic process
GO:0006536 glutamate metabolic process
GO:0009058 biosynthetic process
GO:0032938 negative regulation of translation in response to oxidative stress
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1yaa, PDBe:1yaa, PDBj:1yaa
PDBsum1yaa
PubMed9655342
UniProtP23542|AATC_YEAST Aspartate aminotransferase, cytoplasmic (Gene Name=AAT2)

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