Structure of PDB 1y57 Chain A

Receptor sequence
>1y57A (length=452) Species: 9606 (Homo sapiens) [Search protein sequence]
MVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGY
IPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTK
GAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYS
KHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEV
WMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSE
EPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMN
YVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP
EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRM
PCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGE
NL
3D structure
PDB1y57 The Crystal Structure of a c-Src Complex in an Active Conformation Suggests Possible Steps in c-Src Activation
ChainA
Resolution1.91 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D305 R307 A309 N310 D323 F343
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MPZ A L273 Q275 V281 A293 Y340 M341 G344 L393 L192 Q194 V200 A212 Y259 M260 G263 L312 MOAD: ic50=1633nM
PDBbind-CN: -logKd/Ki=5.79,IC50=1633nM
BindingDB: IC50=7800nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1y57, PDBe:1y57, PDBj:1y57
PDBsum1y57
PubMed15939018
UniProtP12931|SRC_HUMAN Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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