Structure of PDB 1y3i Chain A

Receptor sequence
>1y3iA (length=231) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
VLLVVHLVLVLGGDGTFLRAAELARNASIPVLGVNLGRIGFLAEAEAEAI
DAVLEHVVAQDYRVEDRLTLDVVVRQGGRIVNRGWALNEVSLEKGPRLGV
LGVVVEIDGRPVSAFGCDGVLVSTPTGSTAYAFSAGGPVLWPDLEAILVV
PNNAHALFGRPMVTSPEATIAIEIEADGHDALVFCDGRREMLIPAGSRLE
VTRCVTSVKWARLDSAPFTDRLVRKFRLPVT
3D structure
PDB1y3i NAD-binding mode and the significance of intersubunit contact revealed by the crystal structure of Mycobacterium tuberculosis NAD kinase-NAD complex
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.23: NAD(+) kinase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 NAD A D85 G86 R109 F112 L113 N159 E160 T200 A201 Y202 S205 D14 G15 R38 F41 L42 N88 E89 T129 A130 Y131 S134
Gene Ontology
Molecular Function
GO:0003951 NAD+ kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0006741 NADP biosynthetic process
GO:0006797 polyphosphate metabolic process
GO:0016310 phosphorylation
GO:0019674 NAD metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1y3i, PDBe:1y3i, PDBj:1y3i
PDBsum1y3i
PubMed15629142
UniProtP9WHV7|NADK_MYCTU NAD kinase (Gene Name=ppnK)

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