Structure of PDB 1xx6 Chain A

Receptor sequence
>1xx6A (length=178) Species: 272562 (Clostridium acetobutylicum ATCC 824) [Search protein sequence]
YRPKDHGWVEVIVGPMYSGKSEELIRRIRRAKIAKQKIQVFKPEEDVVSH
MGEKEQAVAIKNSREILKYFEEDTEVIAIDEVQFFDDEIVEIVNKIAESG
RRVICAGLDMDFRGKPFGPIPELMAIAEFVDKIQAICVVCGNPATRTQRL
INGKPAFYDDPVMESYEARCRKCHVVPQ
3D structure
PDB1xx6 X-ray structure of Clostridium acetobutylicum thymidine kinase with ADP. Northeast Structural Genomics Target CAR26.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.21: thymidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C145 C148 C183 C186 C137 C140 C170 C173
BS02 ADP A Y18 S19 G20 K21 S22 E23 S57 H58 M59 I144 Y17 S18 G19 K20 S21 E22 S49 H50 M51 I136
Gene Ontology
Molecular Function
GO:0004797 thymidine kinase activity
GO:0005524 ATP binding
GO:0008270 zinc ion binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0006259 DNA metabolic process
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process
GO:0016310 phosphorylation
GO:0046104 thymidine metabolic process
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1xx6, PDBe:1xx6, PDBj:1xx6
PDBsum1xx6
PubMed
UniProtQ97F65|KITH_CLOAB Thymidine kinase (Gene Name=tdk)

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