Structure of PDB 1xsm Chain A

Receptor sequence
>1xsmA (length=288) Species: 10090 (Mus musculus) [Search protein sequence]
NPSVEDEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDI
QHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEARCFYG
FQIAMENIHSEMYSLLIDTYIKDPKEREYLFNAIETMPCVKKKADWALRW
IGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELIS
RDEGLHCDFACLMFKHLVHKPAEQRVREIITNAVRIEQEFLTEALPVKLI
GMNCTLMKQYIEFVADRLMLELGFNKIFRVENPFDFME
3D structure
PDB1xsm The three-dimensional structure of mammalian ribonucleotide reductase protein R2 reveals a more-accessible iron-radical site than Escherichia coli R2.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y177 D266
Catalytic site (residue number reindexed from 1) Y113 D202
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A E170 E233 E267 H270 E106 E169 E203 H206
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0008199 ferric iron binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001824 blastocyst development
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009262 deoxyribonucleotide metabolic process
GO:0009263 deoxyribonucleotide biosynthetic process
GO:0009265 2'-deoxyribonucleotide biosynthetic process
GO:0051290 protein heterotetramerization
GO:0055086 nucleobase-containing small molecule metabolic process
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1xsm, PDBe:1xsm, PDBj:1xsm
PDBsum1xsm
PubMed8876648
UniProtP11157|RIR2_MOUSE Ribonucleoside-diphosphate reductase subunit M2 (Gene Name=Rrm2)

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