Structure of PDB 1xr3 Chain A

Receptor sequence
>1xr3A (length=256) Species: 1902 (Streptomyces coelicolor) [Search protein sequence]
SEVALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKELREAGV
EADGRTCDVRSVPEIEALVAAVVERYGPVDVLVNNAGRPGGGATAELADE
LWLDVVETNLTGVFRVTKQVLKAGGMLERGTGRIVNIASTGGKQGVVHAA
PYSASKHGVVGFTKALGLELARTGITVNAVCPGFVETPMAASVREHYSDI
WEVSTEEAFDRITARVPIGRYVQPSEVAEMVAYLIGPGAAAVTAQALNVC
GGLGNY
3D structure
PDB1xr3 Structural analysis of actinorhodin polyketide ketoreductase: cofactor binding and substrate specificity.
ChainA
Resolution2.71 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G17 N114 S144 Y157 K161 Y202
Catalytic site (residue number reindexed from 1) G12 N109 S139 Y152 K156 Y197
Enzyme Commision number 1.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G13 T15 S16 G17 I18 A37 R38 G39 C62 D63 V64 N90 A91 G92 S144 Y157 K161 G188 V190 T192 P193 G8 T10 S11 G12 I13 A32 R33 G34 C57 D58 V59 N85 A86 G87 S139 Y152 K156 G183 V185 T187 P188
BS02 ISZ A T145 G146 V151 T140 G141 V146
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0008202 steroid metabolic process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1xr3, PDBe:1xr3, PDBj:1xr3
PDBsum1xr3
PubMed15544323
UniProtP16544|ACT3_STRCO Putative ketoacyl reductase (Gene Name=actIII)

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