Structure of PDB 1xqc Chain A

Receptor sequence
>1xqcA (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSESMMGLLTNLADRELVHMINWAKRVPG
FVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGK
SVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFSTLKS
LEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMS
NKGMEHLYSMPLYDLLLEMLDAHR
3D structure
PDB1xqc Selective Estrogen Receptor Modulators with Conformationally Restricted Side Chains. Synthesis and Structure-Activity Relationship of ERalpha-Selective Tetrahydroisoquinoline Ligands
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AEJ A M343 A350 D351 E353 W383 L387 F404 I424 L525 M27 A34 D35 E37 W67 L71 F88 I108 L207 MOAD: ic50=63nM
PDBbind-CN: -logKd/Ki=7.20,IC50=63nM
BindingDB: EC50=23.2nM,IC50=63nM
External links
PDB RCSB:1xqc, PDBe:1xqc, PDBj:1xqc
PDBsum1xqc
PubMed15658851
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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