Structure of PDB 1xq7 Chain A

Receptor sequence
>1xq7A (length=166) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
MPVVTDKVYFDITIGDEPVGRVVIGLFGNDVPKTVENFKQLASGENGFGY
KGSIFHRVIRNFMIQGGDFTNFDGTGGKSIYGTRFDDENLKIKHFVGAVS
MANAGPNSNGSQFFVTTAPTPWLDGRHVVFGKVVEGMDVVKKVENTKTGL
NDKPKKAVKINDCGVL
3D structure
PDB1xq7 Cyclophilin from Trypanosoma Cruzi Bound to Cyclosporin A
ChainA
Resolution2.07 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R57 F62 Q65 N103 F114 L123 H127
Catalytic site (residue number reindexed from 1) R57 F62 Q65 N103 F114 L123 H127
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R57 F62 Q65 G74 A102 N103 A104 Q112 F114 W122 H127 R57 F62 Q65 G74 A102 N103 A104 Q112 F114 W122 H127
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0006457 protein folding

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Molecular Function
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Biological Process
External links
PDB RCSB:1xq7, PDBe:1xq7, PDBj:1xq7
PDBsum1xq7
PubMed
UniProtQ4DPB9

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