Structure of PDB 1xq3 Chain A

Receptor sequence

>1xq3A (length=243) Species: 9606 (Homo sapiens) [Search protein sequence]

PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIATSCSRRFYQLTKLLDSVQPIARELHQF
TFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ

3D structure

PDB

1xq3 Structural basis for androgen receptor interdomain and coactivator interactions suggests a transition in nuclear receptor activation function dominance

Chain

Resolution

2.25 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	R18	A	L704 N705 L707 Q711 M745 M749 F764 T877	L34 N35 L37 Q41 M75 M79 F94 T201	BindingDB: Kd=0.99nM,IC50=0.302000nM,EC50=0.013000nM,Ki=0.400000nM

External links

PDB	RCSB:1xq3, PDBe:1xq3, PDBj:1xq3
PDBsum	1xq3
PubMed	15525515
UniProt	P10275\|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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