Structure of PDB 1xpm Chain A

Receptor sequence

>1xpmA (length=389)

AIGIDKINFYVPKYYVDMAKLAEARQVDPNKFLIGIGQTEMAVSPVNQDI
VSMGANAAKDIITDEDKKKIGMVIVATESAVDAAKAAAVQIHNLLGIQPF
ARCFEMKEACYAATPAIQLAKDYLATRPNEKVLVIATDTARYGLNSGGEP
TQGAGAVAMVIAHNPSILALNEDAVAYTEDVYDFWRPTGHKYPLVDGALS
KDAYIRSFQQSWNEYAKRQGKSLADFASLCFHVPFTKMGKKALESIIDNA
DETTQERLRSGYEDAVDYNRYVGNIYTGSLYLSLISLLENRDLQAGETIG
LFSYGSGSVGEFYSATLVEGYKDHLDQAAHKALLNNRTEVSVDAYETFFK
RFDDVEFDEEQDAVHEDRHIFYLSNIENNVREYHRPELE

3D structure

• PDB: 1xpm 3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"
• Chain: A
• Resolution: 1.6 Å

Enzymatic activity

• Enzyme Commision number: 2.3.3.10: hydroxymethylglutaryl-CoA synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HMG	A	D29 N31 K32 G36 E79 A110 C111 G148 F185 S201 H233 P235 F236 Y305 S307	D28 N30 K31 G35 E78 A109 C110 G147 F184 S200 H232 P234 F235 Y304 S306
BS02	CAA	A	D29 N31 K32 G36 C111 Y143 G148 F185 S201 H233 P235 F236 N275	D28 N30 K31 G35 C110 Y142 G147 F184 S200 H232 P234 F235 N274

Gene Ontology

Molecular Function

• GO:0004421 hydroxymethylglutaryl-CoA synthase activity
• GO:0016746 acyltransferase activity

Biological Process

• GO:0006084 acetyl-CoA metabolic process
• GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway

External links

• PDB: RCSB:1xpm, PDBe:1xpm, PDBj:1xpm
• PDBsum: 1xpm
• PubMed: 15498869
• UniProt: A0A0H3K1U2