Structure of PDB 1xpg Chain A

Receptor sequence
>1xpgA (length=734) Species: 2336 (Thermotoga maritima) [Search protein sequence]
FTKAYAFGFPKIGEKREFKKALEDFWKGKITEEQFEEEMNKLRMYMVENY
RKNVDVIPSNELSYYDFVLDTAVMVGAVPERFGEYRGLSTYFDMARGGKA
LEMTKFFNTNYHYLVPEIETEEFYLLENKPLEDYLFFKSKGIETAPWVIG
PFTFLYLSKRNGEWIRRPNQMEKLLESLVSVYKEVFEKLVENGCKEILVN
EPAFVCDLEKAHWDLILNVYRELSEFPLTVFTYYDSVSDYEACVSLPVKR
LHFDFVSNEENLKNLEKHGFPEDKKLVAGVINGRQPWKVDLRKVASLVEK
LGASAISNSCPLFHLPVTLELENNLPGGLKEKLAFAKEKLEELKMLKDFL
EGKTFDLPNVSFEDFAVDLQAVERVRNLPEDSFRREKEYTERDRIQRERL
NLPLFPTTTIGSFPQTPEVRKMRSKYRKGEISKEEYEAFIKEQIKKAIEL
QEEIGLDVLVHGEFERTDMVEFFAEKLNGIATTQNGWVLSYGSRCYRPPI
IYGTVTRPEPMTLKEITYAQSLTEKPVKGMLTGPVTIMSWSYYREDIPER
EIAYQIALAINEEVKDLEEAGIKIVQIDEPAFREKAPIKKSKWPEYFEWA
INAFNLAANARPETQIHAHMCYSDFNEIIEYIHQLEFDVISIEASRSKGE
IISAFENFKGWIKQIGVGVWDIHSPAVPSINEMREIVERVLRVLPKELIW
INPDCGLKTRNWDEVIPSLRNMVALAKEMREKFA
3D structure
PDB1xpg Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication
ChainA
Resolution2.59 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.14: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H618 C620 E642 C704 H619 C621 E643 C705
BS02 C2F A K18 K104 S489 R493 C494 W539 E583 K19 K105 S490 R494 C495 W540 E584
BS03 MRY A F106 I587 F107 I588
Gene Ontology
Molecular Function
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0032259 methylation
GO:0071266 'de novo' L-methionine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1xpg, PDBe:1xpg, PDBj:1xpg
PDBsum1xpg
PubMed15630480
UniProtQ9X112|METE_THEMA 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase (Gene Name=metE)

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