Structure of PDB 1xp9 Chain A

Receptor sequence
>1xp9A (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVH
MINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAP
NLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNS
GVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQ
LLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRLHA
3D structure
PDB1xp9 Estrogen receptor ligands. Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrrolidine side chains and linkers.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AIJ A L346 T347 A350 D351 E353 L354 W383 F404 G521 H524 L525 L40 T41 A44 D45 E47 L48 W77 F98 G215 H218 L219 MOAD: ic50=1.3nM
PDBbind-CN: -logKd/Ki=8.89,IC50=1.3nM
BindingDB: IC50=1.3nM
External links
PDB RCSB:1xp9, PDBe:1xp9, PDBj:1xp9
PDBsum1xp9
PubMed15582421
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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