Structure of PDB 1xp0 Chain A

Receptor sequence
>1xp0A (length=326) Species: 9606 (Homo sapiens) [Search protein sequence]
EEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLN
LVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGK
IQNKLTDLEILALLIAALSHDLDHPGVSNQFLINTNSELALMYNDESVLE
HHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRR
GEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELV
ATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEAL
THVSEDCFPLLDGCRKNRQKWQALAE
3D structure
PDB1xp0 Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.
ChainA
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H617 H653 D654 D764 H84 H120 D121 D232
BS02 VDN A Q817 F820 Q285 F288 MOAD: ic50=0.001uM
PDBbind-CN: -logKd/Ki=9.00,IC50=1.0nM
BindingDB: IC50=0.890000nM,Ki=1nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1xp0, PDBe:1xp0, PDBj:1xp0
PDBsum1xp0
PubMed15576036
UniProtO76074|PDE5A_HUMAN cGMP-specific 3',5'-cyclic phosphodiesterase (Gene Name=PDE5A)

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