Structure of PDB 1xos Chain A

Receptor sequence
>1xosA (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
NEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRI
SSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTD
LEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVG
FKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMV
ETKKVTGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEE
FFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQ
PDAQDILDTLEDNRNWYQSMIP
3D structure
PDB1xos Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H238 H274 D275 D392 H77 H113 D114 D229
BS02 VIA A M347 N395 I410 S429 M431 C432 Q443 F446 M186 N232 I247 S266 M268 C269 Q280 F283 MOAD: ic50=20uM
PDBbind-CN: -logKd/Ki=4.70,IC50=20uM
BindingDB: IC50=20000nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1xos, PDBe:1xos, PDBj:1xos
PDBsum1xos
PubMed15576036
UniProtQ07343|PDE4B_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4B (Gene Name=PDE4B)

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