Structure of PDB 1xon Chain A

Receptor sequence
>1xonA (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
TEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTF
KIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVF
TDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLA
VGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKT
MVETKKVVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEE
FFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVH
PDAQDILDTLEDNREWYQSTIP
3D structure
PDB1xon Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.
ChainA
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H164 H200 D201 D318 H79 H115 D116 D229
BS02 PIL A M273 D318 L319 T333 I336 M337 F340 M357 S368 Q369 F372 M188 D229 L230 T244 I247 M248 F251 M268 S279 Q280 F283 MOAD: ic50=0.021nM
PDBbind-CN: -logKd/Ki=10.68,IC50=0.021nM
BindingDB: IC50=21nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1xon, PDBe:1xon, PDBj:1xon
PDBsum1xon
PubMed15576036
UniProtQ08499|PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (Gene Name=PDE4D)

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