Structure of PDB 1xoc Chain A

Receptor sequence

>1xocA (length=504) Species: 1423 (Bacillus subtilis)

KPQQGGDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVK
LSLAESIKELDGGLAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYK
GERGSTYEMLKSVEKKGDYEVLFKLKYKDGNFYNNALDSTAILPKHILGN
VPIADLEENEFNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDT
VTYKVIPDANAAEAQLQAGDINFFNVPATDYKTAEKFNNLKIVTDLALSY
VYIGWNEKNELFKDKKVRQALTTALDRESIVSQVLDGDGEVAYIPESPLS
WNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGDGILDKDGKKFSFTLKT
NQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPPNWDFDAMV
MGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY
SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKW
WLAK

3D structure

• PDB: 1xoc The structure of the oligopeptide-binding protein, AppA, from Bacillus subtilis in complex with a nonapeptide.
• Chain: A
• Resolution: 1.55 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	T41 D42 D43 T46 R119 N151 D154 S155 A263 S265 N367 N370 R373 W398 M405 G418 W419 S420 S422 T423 Y442 Y487 P489 N491 K507	T25 D26 D27 T30 R103 N135 D138 S139 A247 S249 N351 N354 R357 W382 M389 G402 W403 S404 S406 T407 Y426 Y471 P473 N475 K491
BS02	ZN	A	D304 H492	D288 H476
BS03	ZN	A	N348 D350 D354	N332 D334 D338

Gene Ontology

Molecular Function

• GO:1904680 peptide transmembrane transporter activity

Biological Process

• GO:0015031 protein transport
• GO:0015833 peptide transport
• GO:0030420 establishment of competence for transformation
• GO:0030435 sporulation resulting in formation of a cellular spore
• GO:0055085 transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0043190 ATP-binding cassette (ABC) transporter complex

External links

• PDB: RCSB:1xoc, PDBe:1xoc, PDBj:1xoc
• PDBsum: 1xoc
• PubMed: 15588833
• UniProt: P42061|APPA_BACSU Oligopeptide-binding protein AppA (Gene Name=appA)