Structure of PDB 1xnn Chain A

Receptor sequence
>1xnnA (length=247) Species: 10116 (Rattus norvegicus) [Search protein sequence]
IFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKA
LPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFN
EYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGL
KNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIAR
ELHQFAFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT
3D structure
PDB1xnn Structure based approach to the design of bicyclic-1H-isoindole-1,3(2H)-dione based androgen receptor antagonists.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HYQ A L704 N705 L707 G708 Q711 M745 M749 F764 M787 A877 M895 L33 N34 L36 G37 Q40 M74 M78 F93 M116 A206 M224 MOAD: Ki=0.5nM
External links
PDB RCSB:1xnn, PDBe:1xnn, PDBj:1xnn
PDBsum1xnn
PubMed15603938
UniProtP15207|ANDR_RAT Androgen receptor (Gene Name=Ar)

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