Structure of PDB 1xmu Chain A

Receptor sequence
>1xmuA (length=331) Species: 9606 (Homo sapiens) [Search protein sequence]
RFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERD
LLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPA
LDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLE
NHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLL
ADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYR
QWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPL
WETWADLVQPDAQDILDTLEDNRNWYQSMIP
3D structure
PDB1xmu Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H238 H274 D275 D392 H84 H120 D121 D238
BS02 ROF A T345 M347 D392 L393 N395 Y403 W406 T407 I410 S442 Q443 F446 T191 M193 D238 L239 N241 Y249 W252 T253 I256 S288 Q289 F292 MOAD: ic50=0.84nM
PDBbind-CN: -logKd/Ki=9.08,IC50=0.84nM
BindingDB: IC50=0.398nM,Ki=0.398107nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1xmu, PDBe:1xmu, PDBj:1xmu
PDBsum1xmu
PubMed15576036
UniProtQ07343|PDE4B_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4B (Gene Name=PDE4B)

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