Structure of PDB 1xm1 Chain A

Receptor sequence
>1xm1A (length=284) Species: 9606 (Homo sapiens) [Search protein sequence]
ADCGLRPLFEKKSLEDKTERELLESYIIVEGSDAEIGMSPWQVMLFRKSP
QELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYER
NIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDR
ETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVC
KDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMG
IVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQF
3D structure
PDB1xm1 Nonbasic Thrombin Inhibitor Complex
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H70 D126 E229 G230 D231 S232 G233
Enzyme Commision number 3.4.21.5: thrombin.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide A Q38 L65 R73 T74 R75 Y76 K81 I82 M84 Q151 Q51 L87 R95 T96 R97 Y98 K104 I105 M107 Q183
BS02 GAH A H57 W60D E97A N98 L99 D189 A190 C191 E192 S195 V213 S214 W215 G216 E217 G219 H70 W77 E121 N122 L123 D226 A227 C228 E229 S232 V252 S253 W254 G255 E256 G257
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation
Cellular Component
GO:0005576 extracellular region

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1xm1, PDBe:1xm1, PDBj:1xm1
PDBsum1xm1
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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