Structure of PDB 1xk9 Chain A

Receptor sequence
>1xk9A (length=204) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
EFLGDGGDVSFSTRGTQNWTVERLLQAHRQLEERGYVFVGYHGTFLEAAQ
SIVFGGVRARSQDLDAIWRGFYIAGDPALAYGYAQDQEPDARGRIRNGAL
LRVYVPRSSLPGFYRTSLTLAAPEAAGEVERLIGHPLPLRLDAITGPEEE
GGRLETILGWPLAERTVVIPSAIPTDPRNVGGDLDPSSIPDKEQAISALP
DYAS
3D structure
PDB1xk9 Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E553
Catalytic site (residue number reindexed from 1) E155
Enzyme Commision number 2.4.2.36: NAD(+)--diphthamide ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P34 A H440 G441 Y470 I471 A478 Y481 Q485 H42 G43 Y72 I73 A80 Y83 Q87 MOAD: Ki=140nM
PDBbind-CN: -logKd/Ki=6.85,Ki=140nM
Gene Ontology
Molecular Function
GO:0047286 NAD+-diphthamide ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1xk9, PDBe:1xk9, PDBj:1xk9
PDBsum1xk9
PubMed15458385
UniProtP11439|TOXA_PSEAE Exotoxin A (Gene Name=eta)

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