BioLiP

PDB

1xk4 The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins

Chain

Resolution

1.8 Å

3D
structure

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Site
#

Ligand

Ligand
chain

Binding residues on receptor
(original residue number in PDB)

Binding residues on receptor
(residue number reindexed from 1)

Binding affinity

Molecular Function

calcium ion binding

protein binding

microtubule binding

zinc ion binding

Toll-like receptor 4 binding

GO:0046872

metal ion binding

GO:0048306

calcium-dependent protein binding

GO:0050544

arachidonate binding

GO:0050786

RAGE receptor binding

	Biological Process
GO:0002523	leukocyte migration involved in inflammatory response
GO:0002544	chronic inflammatory response
GO:0002790	peptide secretion
GO:0002793	positive regulation of peptide secretion
GO:0006914	autophagy
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006935	chemotaxis
GO:0006954	inflammatory response
GO:0010043	response to zinc ion
GO:0014002	astrocyte development
GO:0018119	peptidyl-cysteine S-nitrosylation
GO:0030307	positive regulation of cell growth
GO:0030593	neutrophil chemotaxis
GO:0032119	sequestering of zinc ion
GO:0032496	response to lipopolysaccharide
GO:0034121	regulation of toll-like receptor signaling pathway
GO:0035425	autocrine signaling
GO:0042742	defense response to bacterium
GO:0045087	innate immune response
GO:0045471	response to ethanol
GO:0050729	positive regulation of inflammatory response
GO:0050832	defense response to fungus
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051493	regulation of cytoskeleton organization
GO:0070488	neutrophil aggregation
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Biological Process

GO:0002523

leukocyte migration involved in inflammatory response

GO:0002544

chronic inflammatory response

GO:0002790

peptide secretion

GO:0002793

positive regulation of peptide secretion

GO:0006914

autophagy

GO:0006915

apoptotic process

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

GO:0006935

chemotaxis

GO:0006954

inflammatory response

GO:0010043

response to zinc ion

GO:0014002

astrocyte development

GO:0018119

peptidyl-cysteine S-nitrosylation

GO:0030307

positive regulation of cell growth

GO:0030593

neutrophil chemotaxis

GO:0032119

sequestering of zinc ion

GO:0032496

response to lipopolysaccharide

GO:0034121

regulation of toll-like receptor signaling pathway

GO:0035425

autocrine signaling

GO:0042742

defense response to bacterium

GO:0045087

innate immune response

GO:0045471

response to ethanol

GO:0050729

positive regulation of inflammatory response

GO:0050832

defense response to fungus

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO:0051493

regulation of cytoskeleton organization

GO:0070488

neutrophil aggregation

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0034774	secretory granule lumen
GO:0045111	intermediate filament cytoskeleton
GO:0062023	collagen-containing extracellular matrix
GO:0070062	extracellular exosome
GO:1990660	calprotectin complex

Cellular Component

extracellular region

extracellular space

nucleus

cytoplasm

cytosol