Structure of PDB 1xjv Chain A

Receptor sequence
>1xjvA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
ATNYIYTPLNQLKGGTIVNVYGVVKFFKPPYLSKGTDYCSVVTIVDQTNV
KLTCLLFSGNYEALPIIYKNGDIVRFHRLKIQVYKKETQGITSSGFASLT
FEGTLGAPIIPRTSSKYFNFTTEDHKMVEALRVWASTHMSTLLKLCDVQP
MQYFDLTCQLLGKAEVDGASFLLKVWDGTRTPFPSWRVLIQDLVLEGDLS
HIHRLQNLTIDILVYDNHVHVARSLKVGSFLRIYSLHTKLQSMNSENQTM
LSLEFHLHGGTSYGRGIRVLPESNSDVDQLKKDLESANLTA
3D structure
PDB1xjv Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
ChainA
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A F31 K33 Y36 S38 K39 G40 T41 D42 T48 L60 F62 Y89 Q94 Y161 Y223 D224 S243 H245 H266 G267 S270 Y271 R273 F26 K28 Y31 S33 K34 G35 T36 D37 T43 L55 F57 Y84 Q89 Y153 Y215 D216 S235 H237 H258 G259 S262 Y263 R265 PDBbind-CN: Kd=9.2nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0043047 single-stranded telomeric DNA binding
Biological Process
GO:0000723 telomere maintenance
Cellular Component
GO:0000781 chromosome, telomeric region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1xjv, PDBe:1xjv, PDBj:1xjv
PDBsum1xjv
PubMed15558049
UniProtQ9NUX5|POTE1_HUMAN Protection of telomeres protein 1 (Gene Name=POT1)

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