Structure of PDB 1xj7 Chain A

Receptor sequence
>1xj7A (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
HIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQL
VHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRML
YFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLL
FSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKL
LDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVK
PIYFHT
3D structure
PDB1xj7 The Molecular Mechanisms of Coactivator Utilization in Ligand-dependent Transactivation by the Androgen Receptor
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V716 K720 R726 M734 Q738 E893 M894 E897 I898 V54 K58 R64 M72 Q76 E231 M232 E235 I236
BS02 DHT A L704 N705 L707 M745 M749 F764 T877 L42 N43 L45 M83 M87 F102 T215 BindingDB: IC50=>10000nM,EC50=6nM,Ki=0.2nM
External links
PDB RCSB:1xj7, PDBe:1xj7, PDBj:1xj7
PDBsum1xj7
PubMed15563469
UniProtP10275|ANDR_HUMAN Androgen receptor (Gene Name=AR)

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