Structure of PDB 1xhl Chain A

Receptor sequence
>1xhlA (length=274) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
RFSGKSVIITGSSNGIGRSAAVIFAKEGAQVTITGRNEDRLEETKQQILK
AGVPAEKINAVVADVTEASGQDDIINTTLAKFGKIDILVNNAGANLADGT
ANTDQPVELYQKTFKLNFQAVIEMTQKTKEHLIKTKGEIVNVSSIVAGPQ
AHSGYPYYACAKAALDQYTRCTAIDLIQHGVRVNSVSPGAVATGFMGAMG
LPETASDKLYSFIGSRKECIPVGHCGKPEEIANIIVFLADRNLSSYIIGQ
SIVADGGSTLVMGMQTHDLMSVLS
3D structure
PDB1xhl Crystal Structure of putative Tropinone Reductase-II from Caenorhabditis Elegans with Cofactor and Substrate
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G17 F26 Q32 N92 S146 Q152 Y157 Y160 K164 E205
Catalytic site (residue number reindexed from 1) G15 F24 Q30 N90 S144 Q150 Y155 Y158 K162 E203
Enzyme Commision number 1.1.1.236: tropinone reductase II.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A G13 S15 G17 I18 R38 N39 R42 D66 V67 N93 A94 G95 L118 S146 K164 P190 G191 V193 T195 G196 F197 G11 S13 G15 I16 R36 N37 R40 D64 V65 N91 A92 G93 L116 S144 K162 P188 G189 V191 T193 G194 F195
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:1xhl, PDBe:1xhl, PDBj:1xhl
PDBsum1xhl
PubMed
UniProtQ19774

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