Structure of PDB 1xg5 Chain A

Receptor sequence
>1xg5A (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
ARPGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEEL
AAECKSAGYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLA
RPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININS
MSGHRVLPLSVTHFYSATKYAVTALTEGLRQELREAQTHIRATCISPGVV
ETQFAFKLHDKDPEKAAATYECLKPEDVAEAVIYVLSTPAHIQIGDIQMR
PTGS
3D structure
PDB1xg5 Structural Genomics Consortium: Structure of the putative human dehydrogenase MGC4172
ChainA
Resolution1.53 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S151 Y166 K170
Catalytic site (residue number reindexed from 1) S150 Y165 K169
Enzyme Commision number 1.1.1.270: 3beta-hydroxysteroid 3-dehydrogenase.
1.1.1.62: 17beta-estradiol 17-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G18 S20 G22 I23 A42 R43 T44 C69 D70 L71 N97 A98 G99 I149 S151 Y166 K170 G199 V201 T203 Q204 F205 K208 G17 S19 G21 I22 A41 R42 T43 C68 D69 L70 N96 A97 G98 I148 S150 Y165 K169 G198 V200 T202 Q203 F204 K207
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:1xg5, PDBe:1xg5, PDBj:1xg5
PDBsum1xg5
PubMed
UniProtQ6UWP2|DHR11_HUMAN Dehydrogenase/reductase SDR family member 11 (Gene Name=DHRS11)

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