Structure of PDB 1xfa Chain A

Receptor sequence
>1xfaA (length=264) Species: 10090 (Mus musculus) [Search protein sequence]
TGIIMENVTAFWEEGFGELLEKSFSHLCLVGNPVLKNINLNIEKGEMLAI
TGSTGSGKTSLLMLILGELEASEGIIKHSGRVSFCSQFSWIMPGTIKENI
IRGVSYDEYRYKSVVKACQLQQDITKFAEQDNTVLGEGGVTLSGGQRARI
SLARAVYKDADLYLLDSPFGYLDVFTEEQVFESCVCKLMANKTRILVTSK
MEHLRKADKILILHQGSSYFYGTFSELQSLRPDFSSKLMGYDTFDQFTEE
RRSSILTETLRRFS
3D structure
PDB1xfa Side chain and backbone contributions of Phe508 to CFTR folding.
ChainA
Resolution3.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T465 Q493 T59 Q87
BS02 ATP A W401 L433 P439 G461 S462 G463 K464 T465 S466 W12 L27 P33 G55 S56 G57 K58 T59 S60
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:1xfa, PDBe:1xfa, PDBj:1xfa
PDBsum1xfa
PubMed15619636
UniProtP26361|CFTR_MOUSE Cystic fibrosis transmembrane conductance regulator (Gene Name=Cftr)

[Back to BioLiP]