Structure of PDB 1xdg Chain A

Receptor sequence

>1xdgA (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]

GNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSY
KTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGAR
PDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKF
ASKPASEFVKILDTFEKLKDLFTELQKKIYVI

3D structure

PDB

1xdg Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo

Chain

Resolution

2.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	S139 S141 D239	S12 S14 D112
BS02	AB8	A	L132 I235 I255 Y257 L302	L5 I108 I128 Y130 L175	MOAD: ic50=0.05uM PDBbind-CN: -logKd/Ki=7.30,IC50=0.05uM BindingDB: IC50=50nM
BS03	AB8	A	V308 I309	V181 I182	MOAD: ic50=0.05uM PDBbind-CN: -logKd/Ki=7.30,IC50=0.05uM BindingDB: IC50=50nM

External links

PDB	RCSB:1xdg, PDBe:1xdg, PDBj:1xdg
PDBsum	1xdg
PubMed	15304496
UniProt	P20701\|ITAL_HUMAN Integrin alpha-L (Gene Name=ITGAL)

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