Structure of PDB 1xdd Chain A

Receptor sequence

>1xddA (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]

GNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSY
KTEFDFSDYVKWKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGAR
PDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKF
ASKPASEFVKILDTFEKLKDLFTELQKKIYVI

3D structure

PDB

1xdd Improved lymphocyte function-associated antigen-1 (LFA-1) inhibition by statin derivatives: molecular basis determined by x-ray analysis and monitoring of LFA-1 conformational changes in vitro and ex vivo

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	S139 S141 D239	S12 S14 D112
BS02	AAY	A	Y166 I235 Y257	Y39 I108 Y130	MOAD: ic50=0.2uM PDBbind-CN: -logKd/Ki=6.70,IC50=0.2uM
BS03	AAY	A	K304 Y307	K177 Y180	MOAD: ic50=0.2uM PDBbind-CN: -logKd/Ki=6.70,IC50=0.2uM

External links

PDB	RCSB:1xdd, PDBe:1xdd, PDBj:1xdd
PDBsum	1xdd
PubMed	15304496
UniProt	P20701\|ITAL_HUMAN Integrin alpha-L (Gene Name=ITGAL)

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