Structure of PDB 1xcl Chain A

Receptor sequence
>1xclA (length=229) Species: 10116 (Rattus norvegicus) [Search protein sequence]
PLFAPGEDCGPAWRAAPAAYDTSDTHLQILGKPVMERWETPYMHSLAAAA
ASRGGRVLEVGFGMAIAASRVQQAPIKEHWIIECNDGVFQRLQNWALKQP
HKVVPLKGLWEEVAPTLPDGHFDGILYDTYPLSEETWHTHQFNFIKTHAF
RLLKPGGILTYCNLTSWGELMKSKYTDITAMFEETQVPALLEAGFQRENI
CTEVMALVPPADCRYYAFPQMITPLVTKH
3D structure
PDB1xcl Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.2: guanidinoacetate N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A W19 V40 M41 M49 G67 F68 G69 M70 I72 A73 E89 C90 L115 W116 D134 T135 L138 W13 V34 M35 M43 G61 F62 G63 M64 I66 A67 E83 C84 L109 W110 D128 T129 L132
BS02 GAI A V40 M41 E45 D134 V34 M35 E39 D128
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0030731 guanidinoacetate N-methyltransferase activity
GO:0042802 identical protein binding
Biological Process
GO:0006601 creatine biosynthetic process
GO:0007283 spermatogenesis
GO:0009887 animal organ morphogenesis
GO:0032259 methylation
GO:0040014 regulation of multicellular organism growth
GO:0046498 S-adenosylhomocysteine metabolic process
GO:0046500 S-adenosylmethionine metabolic process
GO:1990402 embryonic liver development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1xcl, PDBe:1xcl, PDBj:1xcl
PDBsum1xcl
PubMed15533043
UniProtP10868|GAMT_RAT Guanidinoacetate N-methyltransferase (Gene Name=Gamt)

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