Structure of PDB 1x9n Chain A

Receptor sequence

>1x9nA (length=632) Species: 9606 (Homo sapiens) [Search protein sequence]

DPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIEEVSARLRMVET
LSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQA
TGRQLESVRAEAAEKGDVGLVAEMLPPPPLTASGVFSKFRDIARLTGSAS
TAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSL
TPPGQEFPPAMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPV
LLEHGLERLPEHCKLSPGIPLKPMLAHPTRGISEVLKRFEEAAFTCEYKY
DGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKIKLPSVTSFILD
TEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGES
LVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSC
EGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRG
KRAGRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPS
PRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGIS
LRFPRFIRVREDKQPEQATTSAQVACLYRKQS

3D structure

PDB

1x9n Human DNA ligase I completely encircles and partially unwinds nicked DNA.

Chain

Resolution

3.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

6.5.1.1: DNA ligase (ATP).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	E346 G348 G350 Q572 S588 E592 N594 F635 F872	E85 G87 G89 Q303 S319 E323 N325 F366 F603
BS02	dna	A	S303 L306 K493 T798 F800 S801 D802 F872 R874	S42 L45 K224 T529 F531 S532 D533 F603 R605
BS03	dna	A	R305 G416 A418 T420 R451 G453 A455 Q457 S458 R557 Q636 T639 R641 K642 R643 K644 R768 K770 R771 C794 K795 G797 S850 S852 P853 Y855 S869 L870	R44 G147 A149 T151 R182 G184 A186 Q188 S189 R288 Q367 T370 R372 K373 R374 K375 R499 K501 R502 C525 K526 G528 S581 S583 P584 Y586 S600 L601
BS04	AMP	A	Y567 K568 Y569 R573 E621 F660 M723 K725 W742	Y298 K299 Y300 R304 E352 F391 M454 K456 W473

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding

	Biological Process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0071897	DNA biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1x9n, PDBe:1x9n, PDBj:1x9n
PDBsum	1x9n
PubMed	15565146
UniProt	P18858\|DNLI1_HUMAN DNA ligase 1 (Gene Name=LIG1)

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