Structure of PDB 1x7r Chain A

Receptor sequence

>1x7rA (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]

LALSLTADQMVSALLDAEPPILYSESEASMMGLLTNLADRELVHMINWAK
RVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPVKLLFAPNLLLDR
NQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFL
SSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAH

3D structure

PDB

1x7r Understanding the Selectivity of Genistein for Human Estrogen Receptor-Beta Using X-Ray Crystallography and Computational Methods

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I358 K362 L372 V376 E542	I46 K50 L60 V64 E230
BS02	GEN	A	M343 L346 E353 L387 I424 H524 L525	M31 L34 E41 L75 I112 H212 L213	MOAD: ic50=360nM PDBbind-CN: -logKd/Ki=8.05,IC50=9nM BindingDB: IC50=395nM,EC50=240nM,Ki=370nM

External links

PDB	RCSB:1x7r, PDBe:1x7r, PDBj:1x7r
PDBsum	1x7r
PubMed	15576033
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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