Structure of PDB 1x7e Chain A

Receptor sequence
>1x7eA (length=238) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPVKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLIL
SHIRHMSNKGMEHLYSMKCKNVVPLYDLLLEMLDAHRL
3D structure
PDB1x7e Structure-Based Design of Estrogen Receptor-Beta Selective Ligands
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 E380 L539 E542 I54 K58 L68 V72 E76 L228 E231
BS02 244 A L346 E353 F404 M421 I424 L428 H524 L525 L42 E49 F100 M117 I120 L124 H213 L214 PDBbind-CN: -logKd/Ki=5.97,IC50=1062.5nM
BindingDB: IC50=1152nM
External links
PDB RCSB:1x7e, PDBe:1x7e, PDBj:1x7e
PDBsum1x7e
PubMed15548008
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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