Structure of PDB 1x78 Chain A

Receptor sequence
>1x78A (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
LSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISW
AKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVL
DRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMDS
SRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKG
MEHLLNMKCKNVVPVYDLLLEMLNAHVL
3D structure
PDB1x78 Structure-Based Design of Estrogen Receptor-Beta Selective Ligands
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I310 K314 D489 L490 E493 I48 K52 D217 L218 E221
BS02 244 A M295 L298 L301 E305 L339 I376 F377 H475 L476 M33 L36 L39 E43 L77 I114 F115 H203 L204 MOAD: ic50=14nM
PDBbind-CN: -logKd/Ki=7.85,IC50=14.0nM
BindingDB: IC50=14nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1x78, PDBe:1x78, PDBj:1x78
PDBsum1x78
PubMed15548008
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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