Structure of PDB 1x0n Chain A

Receptor sequence
>1x0nA (length=100) Species: 9606 (Homo sapiens) [Search protein sequence]
WFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFK
VLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPT
3D structure
PDB1x0n NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DTF A R67 R86 Q106 H107 F108 K109 L111 W121 R8 R27 Q47 H48 F49 K50 L52 W62 PDBbind-CN: -logKd/Ki=7.70,IC50=20nM
BindingDB: IC50=20nM
External links
PDB RCSB:1x0n, PDBe:1x0n, PDBj:1x0n
PDBsum1x0n
PubMed
UniProtP62993|GRB2_HUMAN Growth factor receptor-bound protein 2 (Gene Name=GRB2)

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