Structure of PDB 1wvj Chain A

Receptor sequence
>1wvjA (length=262) Species: 10116 (Rattus norvegicus) [Search protein sequence]
GANKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFK
YKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVI
DFSKPFMSLGISIMIKKGTPIESAEDLSKQTEIAYGTLDSGSTKEFFRRS
KIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYI
EQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKL
KNKWWYDKGECG
3D structure
PDB1wvj Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IBC A E13 Y61 L90 T91 R96 G141 S142 T143 L192 E193 M196 E13 Y61 L90 T91 R96 G141 S142 T143 L192 E193 M196 MOAD: Ki=185nM
PDBbind-CN: -logKd/Ki=6.73,Ki=185nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1wvj, PDBe:1wvj, PDBj:1wvj
PDBsum1wvj
PubMed15794751
UniProtP19491|GRIA2_RAT Glutamate receptor 2 (Gene Name=Gria2)

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