Structure of PDB 1wvg Chain A

Receptor sequence

>1wvgA (length=352) Species: 220341 (Salmonella enterica subsp. enterica serovar Typhi str. CT18) [Search protein sequence]

SIDKNFWQGKRVFVTGHTGFKGSWLSLWLTEMGAIVKGYALDAPTVPSLF
EIVRLNDLMESHIGDIRDFEKLRSSIAEFKPEIVFHMAAQPLVRLSYEQP
IKTYSTNVMGTVHLLETVKQVGNIKAVVNITSDKCYDNREWVWGYRENEP
MGGYDPYSNSKGCAELVASAFRNSFFNPANYEQHGVGLASVRAGNVIGGG
DWAKDRLIPDILRSFENNQQVIIRNPYSIRPWQHVLEPLSGYIVVAQRLY
TEGAKFSEGWNFGPRDEDAKTVEFIVDKMVTLWGDDASWLLDPHEAHYLK
LDCSKANMQLGWHPRWGLTETLSRIVKWHKAWIRGEDMLICSKREISDYM
SA

3D structure

PDB

1wvg Structure of CDP-D-glucose 4,6-dehydratase from Salmonella typhi complexed with CDP-D-xylose.

Chain

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

4.2.1.45: CDP-glucose 4,6-dehydratase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	APR	A	G18 T20 G21 F22 K23 A42 L43 D67 I68 M89 A90 A91 P93 I132 K163 R208	G16 T18 G19 F20 K21 A40 L41 D65 I66 M87 A88 A89 P91 I130 K161 R206
BS02	CXY	A	P93 K136 Y159 N197 D207 R208 L209 D212 I224 R226 N227 S230 R232 E301	P91 K134 Y157 N195 D205 R206 L207 D210 I222 R224 N225 S228 R230 E295

Gene Ontology

	Molecular Function
GO:0016829	lyase activity
GO:0047733	CDP-glucose 4,6-dehydratase activity

	Biological Process
GO:0009103	lipopolysaccharide biosynthetic process
GO:0009243	O antigen biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1wvg, PDBe:1wvg, PDBj:1wvg
PDBsum	1wvg
PubMed	15805590
UniProt	P26397\|RFBG_SALTY CDP-glucose 4,6-dehydratase (Gene Name=rfbG)

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