Structure of PDB 1wuu Chain A

Receptor sequence
>1wuuA (length=391) Species: 9606 (Homo sapiens) [Search protein sequence]
HHAALRQPQVAELLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQ
GLVLPMALELMTVLVGSPRKDGLVSLLTTSEGADEPQRLQFPLPTAQRSL
EPGTPRWANYVKGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVAT
YTFLQQLCPDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHAL
LIDCRSLETSLVPLSDPKLAVLITNSNVRHASSEYPVRRRQCEEVARALG
KESLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYR
AFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGC
TVTLLEASAAPHAMRHIQEHYGGTATFYLSQAADGAKVLCL
3D structure
PDB1wuu Molecular Structure of Human Galactokinase: IMPLICATIONS FOR TYPE II GALACTOSEMIA
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.6: galactokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLA A E43 H44 D46 Y47 G183 M185 D186 Y236 E44 H45 D47 Y48 G184 M186 D187 Y235
BS02 ANP A T77 S79 W106 Y109 L135 G136 G138 S140 S141 S142 L145 T78 S80 W107 Y110 L136 G137 G139 S141 S142 S143 L146
Gene Ontology
Molecular Function
GO:0004335 galactokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005534 galactose binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0006012 galactose metabolic process
GO:0016310 phosphorylation
GO:0019402 galactitol metabolic process
GO:0033499 galactose catabolic process via UDP-galactose
GO:0046835 carbohydrate phosphorylation
GO:0061623 glycolytic process from galactose
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1wuu, PDBe:1wuu, PDBj:1wuu
PDBsum1wuu
PubMed15590630
UniProtP51570|GALK1_HUMAN Galactokinase (Gene Name=GALK1)

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