Structure of PDB 1wum Chain A

Receptor sequence
>1wumA (length=118) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVI
RFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCAN
ILEKFFFSKIKEAGLIDK
3D structure
PDB1wum Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
2.3.1.57: diamine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NP2 A E750 V752 E756 A757 Y802 Y809 E36 V38 E42 A43 Y88 Y95 PDBbind-CN: -logKd/Ki=5.29,IC50=5.1uM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1wum, PDBe:1wum, PDBj:1wum
PDBsum1wum
PubMed15724976
UniProtQ92831|KAT2B_HUMAN Histone acetyltransferase KAT2B (Gene Name=KAT2B)

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