Structure of PDB 1wug Chain A

Receptor sequence
>1wugA (length=118) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMSKEPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVI
RFPMDLKTMSERLKNRYYVSKKLFMADLQRVFTNCKEYNPPESEYYKCAN
ILEKFFFSKIKEAGLIDK
3D structure
PDB1wug Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
ChainA
ResolutionN/A
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
2.3.1.57: diamine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NP1 A E750 V752 E756 A757 Y802 Y809 E36 V38 E42 A43 Y88 Y95 PDBbind-CN: -logKd/Ki=5.80,IC50=1.6uM
BindingDB: IC50=1600nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:1wug, PDBe:1wug, PDBj:1wug
PDBsum1wug
PubMed15724976
UniProtQ92831|KAT2B_HUMAN Histone acetyltransferase KAT2B (Gene Name=KAT2B)

[Back to BioLiP]