Structure of PDB 1wsv Chain A

Receptor sequence
>1wsvA (length=371) Species: 9606 (Homo sapiens) [Search protein sequence]
VLRRTPLYDFHLAHGGKMVAFAGWSLPVQYRDSHTDSHLHTRQHCSLFDV
SHMLQTKILGSDRVKLMESLVVGDIAELRPNQGTLSLFTNEAGGILDDLI
VTNTSEGHLYVVSNAGCWEKDLALMQDKVRELQNQGRDVGLEVLDNALLA
LQGPTAAQVLQAGVADDLRKLPFMTSAVMEVFGVSGCRVTRCGYTGEDGV
EISVPVAGAVHLATAILKNPEVKLAGLAARDSLRLEAGLCLYGNDIDEHT
TPVEGSLSWTLGKRRRAAMDFPGAKVIVPQLKGRVQRRRVGLMCEGAPMR
AHSPILNMEGTKIGTVTSGCPSPSLKKNVAMGYVPCEYSRPGTMLLVEVR
RKQQMAVVSKMPFVPTNYYTL
3D structure
PDB1wsv Crystal Structure of Human T-protein of Glycine Cleavage System at 2.0A Resolution and its Implication for Understanding Non-ketotic Hyperglycinemia
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D101
Catalytic site (residue number reindexed from 1) D98
Enzyme Commision number 2.1.2.10: aminomethyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 THH A M56 L88 D101 L102 I103 V115 N117 F176 G196 Y197 E204 R233 L242 Y371 M53 L85 D98 L99 I100 V112 N114 F173 G193 Y194 E201 R230 L239 Y368
Gene Ontology
Molecular Function
GO:0004047 aminomethyltransferase activity
GO:0008483 transaminase activity
Biological Process
GO:0006546 glycine catabolic process
GO:0019464 glycine decarboxylation via glycine cleavage system
Cellular Component
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005960 glycine cleavage complex

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Cellular Component
External links
PDB RCSB:1wsv, PDBe:1wsv, PDBj:1wsv
PDBsum1wsv
PubMed16051266
UniProtP48728|GCST_HUMAN Aminomethyltransferase, mitochondrial (Gene Name=AMT)

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