Structure of PDB 1wp4 Chain A

Receptor sequence
>1wp4A (length=288) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
EKVAFIGLGAMGYPMAGHLARRFPTLVWNRTFEKALRHQEEFGSEAVPLE
RVAEARVIFTCLPTTREVYEVAEALYPYLREGTYWVDATSGEPEASRRLA
ERLREKGVTYLDAPVSGGTSGAEAGTLTVMLGGPEEAVERVRPFLAYAKK
VVHVGPVGAGHAVKAINNALLAVNLWAAGEGLLALVKQGVSAEKALEVIN
ASSGRSNATENLIPQRVLTRAFPKTFALGLLVKDLGIAMGVLDGEKAPSP
LLRLAREVYEMAKRELGPDADHVEALRLLERWGGVEIR
3D structure
PDB1wp4 Crystal Structure of Novel NADP-dependent 3-Hydroxyisobutyrate Dehydrogenase from Thermus thermophilus HB8
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S117 K165 N168 N169
Catalytic site (residue number reindexed from 1) S116 K164 N167 N168
Enzyme Commision number 1.1.1.31: 3-hydroxyisobutyrate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A S117 G118 G119 K165 S116 G117 G118 K164
BS02 NDP A G8 L9 G10 A11 M12 N30 R31 T32 K35 C62 L63 P64 E68 S91 V116 T226 F227 K234 G7 L8 G9 A10 M11 N29 R30 T31 K34 C61 L62 P63 E67 S90 V115 T225 F226 K233
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0016054 organic acid catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1wp4, PDBe:1wp4, PDBj:1wp4
PDBsum1wp4
PubMed16126223
UniProtQ5SLQ6

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