Structure of PDB 1wle Chain A

Receptor sequence
>1wleA (length=465) Species: 9913 (Bos taurus) [Search protein sequence]
RNLLYEHAREGYSALPLLDMESLCAYPEDAARALDLRKGELRSKDLPGII
STWQELRQLREQIRSLEEEKEAVTEAVRALVVNQDNSQVQQDPQYQSLRA
RGREIRKQLTLLYPKEAQLEEQFYLRALRLPNQTHPDVPVGDESQARVLH
VVGDKPAFSFQPRGHLEIAEKLDIIRQKRLSHVSGHRSYYLRGAGALLQH
GLVNFTLNKLIHRGFTPMTVPDLLRGVVFEGCGMTPNAKPSQIYNIDPSR
FEDLNLAGTAEVGLAGYFMDHSVAFRDLPIRMVCSSTCYRAETDTGPWGL
YRVHHFTKVEMFGVTGPGLEQSSELLEEFLSLQMEILTELGLHFRVLDMP
TQELGLPAYRKFDIEAWMPGRGRFGEVTSASNCTDFQSRRLHIMFQTEAG
ELQFAHTVNATGCAVPRLLIALLESYQQKDGSVLVPPALQPYLGTDRITT
PTHVPLQYIGPNQPQ
3D structure
PDB1wle Dual-mode recognition of noncanonical tRNAs(Ser) by seryl-tRNA synthetase in mammalian mitochondria
ChainA
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R313 R327 E401 S404 R442
Catalytic site (residue number reindexed from 1) R290 R302 E376 S379 R417
Enzyme Commision number 6.1.1.11: serine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SRP A T282 E284 R313 E315 Y326 V328 F331 E335 E401 V402 T403 S404 N434 T436 A439 T259 E261 R290 E292 Y301 V303 F306 E310 E376 V377 T378 S379 N409 T411 A414
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004828 serine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006434 seryl-tRNA aminoacylation
GO:0070158 mitochondrial seryl-tRNA aminoacylation
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1wle, PDBe:1wle, PDBj:1wle
PDBsum1wle
PubMed16163389
UniProtQ9N0F3|SYSM_BOVIN Serine--tRNA ligase, mitochondrial (Gene Name=SARS2)

[Back to BioLiP]