Structure of PDB 1wkv Chain A

Receptor sequence

>1wkvA (length=382) Species: 272557 (Aeropyrum pernix K1)

ALADISGYLDVLDSVRGFSYLENAREVLRSGEARCLGNPRSEPEYVKALY
VIGASRIPVGDGCSHTLEELGVFDISVPGEMVFPSPLDFFERGKPTPLVR
SRLQLPNGVRVWLKLEWYNPFSLSVKDRPAVEIISRLSRRVEKGSLVADA
TSSNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAP
STVHLLPRVMKDSKNEGFVHVNQFYNDANFEAHMRGTAREIFVQSRRGGL
ALRGVAGSLGTSGHMSAAAFYLQSVDPSIRAVLVQPAQGDSIPGIRRVET
GMLWINMLDISYTLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAK
KAAEGDLEPGDYVVVVPDTGFKYLSLVQNALE

3D structure

• PDB: 1wkv Three-dimensional Structure of a New Enzyme, O-Phosphoserine Sulfhydrylase, involved in l-Cysteine Biosynthesis by a Hyperthermophilic Archaeon, Aeropyrum pernix K1, at 2.0A Resolution
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K127 S341
• Catalytic site (residue number reindexed from 1): K126 S340
• Enzyme Commision number: 2.5.1.47: cysteine synthase.
  2.5.1.65: O-phosphoserine sulfhydrylase.
  4.2.1.22: cystathionine beta-synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PLP	A	K127 N155 G261 T262 S263 H265 I296 S341 P368 D369	K126 N154 G260 T261 S262 H264 I295 S340 P367 D368

Gene Ontology

Molecular Function

• GO:0004122 cystathionine beta-synthase activity
• GO:0004124 cysteine synthase activity
• GO:0016740 transferase activity
• GO:0016829 lyase activity
• GO:0033847 O-phosphoserine sulfhydrylase activity

Biological Process

• GO:0006534 cysteine metabolic process
• GO:0006535 cysteine biosynthetic process from serine
• GO:0009069 serine family amino acid metabolic process
• GO:0019344 cysteine biosynthetic process
• GO:0044272 sulfur compound biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:1wkv, PDBe:1wkv, PDBj:1wkv
• PDBsum: 1wkv
• PubMed: 16005886
• UniProt: Q9YBL2|CYSO_AERPE Protein CysO (Gene Name=cysO)