Structure of PDB 1wd9 Chain A

Receptor sequence
>1wd9A (length=603) Species: 9606 (Homo sapiens) [Search protein sequence]
GTLIRVTPEQPTHAVCVLGTLTQLDICSSASFSINASPGVVVDIAWPLDP
GVEVTLTMKAASGSTGDQKVQISYYKTPPVKALLYLTAVEISLCADITRT
QRTWTWGPCGQGAILLVNCDRDNLESSAMDCEDDEVLDSEDLQDMSLMTL
STKTPKDFFTNHTLVLHVARSEMDKVRVFQATCSVVLGPKWPSHYLMVPG
GKHNMDFYVEALAFPDTDFPGLITLTISLLDTSNLELPEAVVFQDSVVFR
VAPWIMTPNTQPPQEVYACSEDFLKSVTTLAMKAKCKLTICPQWMQDEME
IGYIQAPHKTLPVVFDSPRNRGLKEFPIKRVMGPDFGYVTRGPQTGGISG
LDSFGNLEVSPPVTVRGKEYPLGRILFGDSCYPSNDSRQMHQALQDFLSA
QQVQAPVKLYSDWLSVGHVDEFLSFVPAPDRKGFRLLLASPRSCYKLFQE
QQNEGHGEALLFQQKIKNILSNKTLREHNSFVERCIDWNRELLKRELGLA
ESDIIDIPQLFKLKEFSKAEAFFPNMVNMLVLGKHLGIPKPFGPVINGRC
CLEEKVCSLLEPLGLQCTFINDFFTYHIRHGEVHAGTNVRRKPFSFKWWN
MVP
3D structure
PDB1wd9 Structural basis for Ca(2+)-induced activation of human PAD4
ChainA
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D350 H471 D473 A645
Catalytic site (residue number reindexed from 1) D297 H418 D420 A585
Enzyme Commision number 3.5.3.15: protein-arginine deiminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A Q349 E353 F407 G408 L410 E411 Q296 E300 F354 G355 L357 E358
BS02 CA A N153 D155 D157 D165 D176 D179 N118 D120 D122 D130 D141 D144
BS03 CA A D155 D157 D179 D388 D120 D122 D144 D335
BS04 CA A E351 D369 S370 N373 E298 D316 S317 N320
BS05 CA A D165 D168 E170 D130 D133 E135
Gene Ontology
Molecular Function
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0140794 histone arginine deiminase activity
GO:0140795 histone H3R2 arginine deiminase activity
GO:0140796 histone H3R8 arginine deiminase activity
GO:0140797 histone H3R17 arginine deiminase activity
GO:0140798 histone H3R26 arginine deiminase activity
Biological Process
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006338 chromatin remodeling
GO:0019827 stem cell population maintenance
GO:0036211 protein modification process
GO:0043687 post-translational protein modification
GO:0045087 innate immune response
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1wd9, PDBe:1wd9, PDBj:1wd9
PDBsum1wd9
PubMed15247907
UniProtQ9UM07|PADI4_HUMAN Protein-arginine deiminase type-4 (Gene Name=PADI4)

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