Structure of PDB 1wcf Chain A

Receptor sequence
>1wcfA (length=162) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
HMQFDVTIEIPKGQRNKYEVDHETGRVRLDRYLYTPMAYPTDYGFIEDTL
GDDGDPLDALVLLPQPVFPGVLVAARPVGMFRMVDEHGGDDKVLCVPAGD
PRWDHVQDIGDVPAFELDAIKHFFVHYKDLEPGKFVKAADWVDRAEAEAE
VQRSVERFKAGT
3D structure
PDB1wcf Structure of the Mycobacterium Tuberculosis Soluble Inorganic Pyrophosphatase Rv3628 at Ph 7.0.
ChainA
Resolution1.54 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.1: inorganic diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K A K127 D128 L129 E130 P131 K133 K128 D129 L130 E131 P132 K134
BS02 K A D52 P55 D57 D89 D53 P56 D58 D90
BS03 PO4 A K16 R30 Y126 K17 R31 Y127
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphate phosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006796 phosphate-containing compound metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0044228 host cell surface

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Cellular Component
External links
PDB RCSB:1wcf, PDBe:1wcf, PDBj:1wcf
PDBsum1wcf
PubMed21821883
UniProtP9WI55|IPYR_MYCTU Inorganic pyrophosphatase (Gene Name=ppa)

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