Structure of PDB 1wc0 Chain A

Receptor sequence
>1wc0A (length=198) Species: 118562 (Arthrospira platensis) [Search protein sequence]
SHMRPEPRLITILFSDIVGFTRMSNALQSQGVAELLNEYLGEMTRAVFEN
QGTVDKFVGDAIMALYGAPEEMSPSEQVRRAIATARQMLVALEKLNQGWQ
ERGLVGRNEVPPVRFRCGIHQGMAVVGLFGSQERSDFTAIGPSVNIAARL
QEATAPNSIMVSAMVAQYVPDEEIIKREFLELKGIDEPVMTCVINPNM
3D structure
PDB1wc0 Bicarbonate Activation of Adenylyl Cyclase Via Promotion of Catalytic Active Site Closure and Metal Recruitment
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.13.3: histidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 APC A I1018 V1019 T1022 V1059 G1060 D1061 I17 V18 T21 V58 G59 D60 MOAD: Ki=0.3mM
BS02 CA A D1017 I1018 D1061 D16 I17 D60
BS03 APC A K1057 M1064 V1145 N1146 A1149 R1150 K1184 K56 M63 V144 N145 A148 R149 K183 MOAD: Ki=0.3mM
Gene Ontology
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:1wc0, PDBe:1wc0, PDBj:1wc0
PDBsum1wc0
PubMed15619637
UniProtO32393

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