Structure of PDB 1wbk Chain A

Receptor sequence

>1wbkA (length=99) Species: 11676 (Human immunodeficiency virus 1)

PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGI
GGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

3D structure

• PDB: 1wbk Design and Synthesis of HIV-1 Protease Inhibitors. Novel Tetrahydrofuran P2 and P2'-Groups Interacting with Asp29 and 30 of the HIV-1 Protease. Determination of Binding from X-Ray Crystal Structure of Inhibitor Protease Complex
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D25 T26 G27
• Catalytic site (residue number reindexed from 1): D25 T26 G27

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	568	A	R8 D25 G27 D29 D30 V82	R8 D25 G27 D29 D30 V82

Gene Ontology

Molecular Function

• GO:0004190 aspartic-type endopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:1wbk, PDBe:1wbk, PDBj:1wbk
• PDBsum: 1wbk
• UniProt: Q8Q3H0