Structure of PDB 1war Chain A

Receptor sequence
>1warA (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
EAEAEFATPALRFVAVGDWGGVPNAPFHTAREMANAKEIARTVQILGADF
ILSLGDNFYFTGVQDINDKRFQETFEDVFSDRSLRKVPWYVLAGNHDHLG
NVSAQIAYSKISKRWNFPSPFYRLHFKIPQTNVSVAIFMLDTVTLCGNSD
DFLSQQPERPRDVKLARTQLSWLKKQLAAAREDYVLVAGHYPVWSIAEHG
PTHCLVKQLRPLLATYGVTAYLCGHDHNLQYLQDENGVGYVLSGAGNFMD
PSKRHQRKVPNGYLRFHYGTEDSLGGFAYVEISSKEMTVTYIEASGKSLF
KTRLPRRARP
3D structure
PDB1war Crystal Structures of Recombinant Human Purple Acid Phosphatase with and without an Inhibitory Conformation of the Repression Loop.
ChainA
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.2: acid phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A D12 D50 Y53 H221 D18 D56 Y59 H227
BS02 FE A D50 N89 H184 H219 D56 N95 H190 H225
BS03 PO4 A D50 Y53 N89 H90 H193 H219 H221 D56 Y59 N95 H96 H199 H225 H227
Gene Ontology
Molecular Function
GO:0003993 acid phosphatase activity
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:1war, PDBe:1war, PDBj:1war
PDBsum1war
PubMed15993892
UniProtP13686|PPA5_HUMAN Tartrate-resistant acid phosphatase type 5 (Gene Name=ACP5)

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