Structure of PDB 1w7l Chain A

Receptor sequence
>1w7lA (length=415) Species: 9606 (Homo sapiens) [Search protein sequence]
QLQARRLDGIDYNPWVEFVKLASEHDVVNLGQGFPDFPPPDFAVEAFQHA
VSGDFMLNQYTKTFGYPPLTKILASFFGELLGQEIDPLRNVLVTVGGYGA
LFTAFQALVDEGDEVIIIEPFFDCYEPMTMMAGGRPVFVSLKPGPGELGS
SSNWQLDPMELAGKFTSRTKALVLNTPNNPLGKVFSREELELVASLCQQH
DVVCITDEVYQWMVYDGHQHISIASLPGMWERTLTIGSAGKTFSATGWKV
GWVLGPDHIMKHLRTVHQNSVFHCPTQSQAAVAESFEREQLLFRQPSSYF
VQFPQAMQRCRDHMIRSLQSVGLKPLIPQGSYFLITDISDFKRKMPDLPG
AVDEPYDRRFVKWMIKNKGLVAIPVSIFYSVPHQKHFDHYIRFCFVKDEA
TLQAMDEKLRKWKVE
3D structure
PDB1w7l Crystal Structure of Human Kynurenine Aminotransferase I
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F125 D213 V215 K247
Catalytic site (residue number reindexed from 1) F122 D207 V209 K241
Enzyme Commision number 2.6.1.64: glutamine--phenylpyruvate transaminase.
2.6.1.7: kynurenine--oxoglutarate transaminase.
4.4.1.13: cysteine-S-conjugate beta-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A G99 G100 Y101 F125 N181 N185 D213 V215 Y216 S244 K247 K255 G96 G97 Y98 F122 N175 N179 D207 V209 Y210 S238 K241 K249
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008483 transaminase activity
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
GO:0047316 glutamine-phenylpyruvate transaminase activity
GO:0047804 cysteine-S-conjugate beta-lyase activity
Biological Process
GO:0009058 biosynthetic process
GO:0009617 response to bacterium
GO:0070189 kynurenine metabolic process
GO:0097053 L-kynurenine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1w7l, PDBe:1w7l, PDBj:1w7l
PDBsum1w7l
PubMed15364907
UniProtQ16773|KAT1_HUMAN Kynurenine--oxoglutarate transaminase 1 (Gene Name=KYAT1)

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