Structure of PDB 1w68 Chain A

Receptor sequence
>1w68A (length=281) Species: 10090 (Mus musculus) [Search protein sequence]
VEDEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHW
EALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQI
AMENIHSEMYSLLIDTYIKDPKEREYLFNAIETMPCVKKKADWALRWIGD
KEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDE
GLHCDFACLMFKHLVHKPAEQRVREIITNAVRIEQEFLTEALPVKLIGMN
CTLMKQYIEFVADRLMLELGFNKIFRVENPF
3D structure
PDB1w68 Crystal Structural Studies of Changes in the Native Dinuclear Iron Center of Ribonucleotide Reductase Protein R2 from Mouse
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y177 D266
Catalytic site (residue number reindexed from 1) Y110 D199
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FEO A D139 E170 H173 E233 E267 H270 D72 E103 H106 E166 E200 H203
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0008199 ferric iron binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001824 blastocyst development
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009262 deoxyribonucleotide metabolic process
GO:0009263 deoxyribonucleotide biosynthetic process
GO:0009265 2'-deoxyribonucleotide biosynthetic process
GO:0051290 protein heterotetramerization
GO:0055086 nucleobase-containing small molecule metabolic process
GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1w68, PDBe:1w68, PDBj:1w68
PDBsum1w68
PubMed15322079
UniProtP11157|RIR2_MOUSE Ribonucleoside-diphosphate reductase subunit M2 (Gene Name=Rrm2)

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